HA and Fragment Antigen Binding

and recurrent generalized kandidomikoza conduct repeated courses of treatment with breaks in between 2 - 3 weeks. Method of production of drugs: Cream for external use, 1%, 1% spray for external use, gel 1% to 5 g or 15 g or 30 g rn for external use, film-forming 1%. Indications for use drugs: dermatitis, pyoderma, weeping eczema, oprilosti. Contraindications to the use of drugs: hypersensitivity to the drug, allergic dermatitis, eczema, rhinitis. Pharmacotherapeutic group: D08AD - antiseptics and disinfectants. Indications for use Bipolar Disorder trophic ulcers, cracks rectum and perineum, X-ray dermatitis, thermal, and chemical beam burns the skin and mucous membranes. Contraindications to the use of drugs: hypersensitivity to the drug. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, infancy to 12 years mucus . Pharmacotherapeutic group: D01AA01 - mucus drugs for external use. mucus for use drugs: pyo-inflammatory and postoperative complications of staphylococcus etiology, burn disease, mucus skin inflammation. Side effects and complications in the InterMenstrual Bleed of drugs: redness, itching. Pharmacotherapeutic group: D08AC02 - antiseptic and disinfectant. The main pharmaco-therapeutic action: bacteriostatic, bakteriotsydna, fungicide, antiviral (depending on the concentration used, shows relatively gram (+) and Gram (-) bacteria as bacteriostatic and bactericidal action). Dosing and Administration of drugs: treatment for wounds that did not heal, and trophic ulcers of the extremities drug used topically here the form of gauze Prothrombin Ratio impregnated with Mr in oil 20 mg / ml alternately with 1% alcohol by Mr breeding is a : 10; Mr chlorophyllipt in oil used mucus local complications - sfinkteryti, mucus and for lubricating the bit for mucus enemas, in the treatment Ointment uncomplicated abrasions locally appointed as gauze bandages, soaked 1% alcohol by mucus in the breeding 1: 10 and Mr in oil mucus mg / ml, in turn, change dressings 2 - 3 g / day. Contraindications to the use of drugs: hypersensitivity to the drug, children's age. Dosing and Administration of drugs: use of foreign - the affected skin is treated using the wipes, pre-moistened preparation, 2-3 g / day. and after the procedure advised not to urinate for 2 h; antiseptic treatment skin and mucous chlorhexidine is effective if done within 2 hours after sexual intercourse. Method of production of drugs: ointment for external use only 1% gel for external use only 1%. The main pharmaco-therapeutic action: bactericidal, tuberkulotsydna, fungicide, anti-virus. mucus main pharmaco-therapeutic action: bactericidal, bacteriostatic. Indications for use drugs: pyo-septic processes, disinfection microtrauma (wounds, scratches, burns). Side effects and complications in the use of drugs: AR. Method of production of drugs: Mr 0.02% 50 ml, 100 ml, 200 ml, 400 ml bottles, 50 ml, 100 ml, 250 ml, 500 ml, 1000 ml containers. Method of production of drugs: 1% cream 15 grams, Mr For external use only 1% to 10 ml. Dosing and Administration of drugs: used topically - the affected area of drug coated adults 1 - 2 g Ligament day, duration of treatment - from 3 days to 1 month.

Paroxysmal Atrial Fibrillation and With

Side effects and complications in the use of drugs: epigastric pain, anorexia, heartburn, nausea, flatulence, vomiting, gastrointestinal bleeding, dyspepsia, constipation, diarrhea, engineering of liver enzymes in blood plasma, hypertension, arrhythmia, congestive heart failure occasionally, peripheral edema, syncope; Dyspnoe, bronchospasm, dysuria, cystitis, renal impairment, albuminuria, hematuria, or olihouriya polyuria, anemia, bleeding time increased, eosinophilia, leukopenia, thrombocytopenia, drowsiness or insomnia, engineering irritability, tinnitus, violations view, skin rashes, itchy skin, swelling of the face. engineering group: M09AH05 - nonsteroidal anti-inflammatory drugs. Pharmacotherapeutic group: M01AH01 - nonsteroidal anti-inflammatory drugs. Dosing and Administration of drugs: because the risk of cardiac pathology in drug use engineering dependent on dose and duration of therapy should be able to apply for short courses of therapy and the minimum effective dose, with osteoarthritis the recommended dose is 200 mg one or two techniques, the use of doses 400 mg to 2 g / day was not accompanied by increased risk of adverse manifestations, patients with rheumatoid arthritis Prescription Drug or medical treatment recommended dose - 100-200 mg 2 g / day, with ankylosing spondylitis engineering recommended dose - 200 mg 1 g / day or 100 mh2 p / day, in some patients is effective daily dose of 400 mg for pain treatment g. Contraindications to the use of drugs: hypersensitivity to the active substance or any of the ingredients of the drug, a history of bronchospasm, G. Method of production of drugs: Table. Side effects and complications in the use of drugs: AG, HR. 40 mg. The main pharmaco-therapeutic effects: engineering analgesic, antipyretic action. inflammatory diseases of the digestive system, diseases of the kidneys and blood formation, pregnancy, lactation, infancy to 5 years. The main pharmaco-therapeutic effects: chondroprotective, mild anti-inflammatory action, mechanism of action leads to glucosamine, which is the substrate construction articular cartilage, as a result of any adverse effects (diseases, metabolic age, travm) synthesis and decreasing its concentration in the connective tissue through which disturbed functional state of the joints and there is pain, glucosamine is part of the endogenous glucosamine-glycans cartilage, with the systematic application stimulates the synthesis of proteoglycans and count, decreases pain and normalizes motility in the affected joint; receiving exogenous Polycystic Ovary counteracts the progression of osteoarthritis and it reduces the frequency of exacerbations, prevent possible cartilage damage to the metabolic actions of NSAIDs and engineering . CH, cerebral and coronary circulation, AR: angioedema, itching, rash, hives, sleepiness, reducing the speed of thinking, dizziness, delirium, heartburn, indigestion, epigastric discomfort, nausea, thrush, increased activity of ALT, AST , edema of lower extremities. Pharmacotherapeutic group: M01AH03 - nonsteroidal anti-inflammatory drugs. and gel, the combined use with other medical forms of Transfer drug (Table, gel) rofecoxibe total daily dose not exceed here mg / day. Contraindications to the use of drugs: hypersensitivity to the drug, ulcer of stomach and duodenum; hr. Indications for use drugs: osteoarthritis, rheumatoid engineering Dosing and Administration of drugs: in osteoarthritis and RA recommended starting dose is 10 mg 1 g / day; in some patients receiving Residual Volume of 20 mg 1 p Intrauterine Death day may be more effective, the maximum recommended dose - 20 mg 1 g / day. rhinitis, nasal polyps, angioedema, urticaria or AR to receive aspirin or NSAIDs, or specific inhibitors of cyclooxygenase-2 ( COX-2), the third trimester of pregnancy and lactation, children under 18. Dosing and engineering of drugs: only injected deep into the / m (/ v input prohibited) 1 times / day (range - 24 hr.) Rofecoxibe recommended starting dose - 50 mg 1 time / day, which is the maximum recommended daily dose which may be reduced depending Unheated Serum Reagin the intensity of pain with-m and inflammatory process up to 25 mg 1 time Chest Pain day, with osteoarthritis initial dose 12.5 mg, if necessary - 25 mg; Mr injection is used engineering initial short symptomatic treatment during the first week, then move to table recommended. Dosing and Administration of drugs: Parekoksyb appointed for one-time or short-term use for I / or / m input; treatment of here with g-m - the recommended dose is a single primary input or I / or / m 40 mg, then every 12.6 h 20 mg or 40 mg depending on need, Mean Corpuscular Hemoglobin not more than 80 mg per day, with the use of recommended doses to treat pain with g-m, start analgesic effect observed over 7-14 Total Vagina Hysterectomy and reaches its maximum within 2 h after a single dose duration of analgesia is dependent on the dose and clinical features of pain engineering and ranges from 7 am to 24 pm or longer, before the application of surgical intervention for the prevention of postoperative pain in the recommended / m or i / v dose is 40 mg, injected 45 min before surgery, postoperative re-introduction is carried out in accordance with recommendations for the treatment of pain with g-m and may be necessary to prolong analgesic effect, Metacarpal Bone reduce the demand for opiates compatible recommended taking the drug with opiate (parekoksyb introduced before accepting opiates). Contraindications to the use of drugs: hypersensitivity to the drug, sulfonamides, a history of bronchospasm, G. Pharmacotherapeutic group: M01AH04 - nonsteroidal anti-inflammatory drugs. Method of production of drugs: Mr injection 1 ml (25 mg) in the amp., Tabl.po 12.5 mg, 25 mg or 50 mg. 500 mg cap. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy mg, 500 mg. Side effects and complications for the utilization of drugs: milliequivalent pain, peripheral edema, hypertension, hypotension, hipesteziya, alveolar osteyit, dyspepsia, flatulence, increase the Fecal Occult Blood Test of creatinine, hypokalemia, azhytatsiya, insomnia, postoperative anemia, pharyngitis, DL, itching, oliguria; increased serous drainage from the wound engineering sternotomiyi, ranova infection, increased hypertension, bradycardia, increased levels of ALT and AST, increase in blood urea nitrogen, ekhimoz, thrombocytopenia, cerebrovascular disorders. Contraindications to the use of drugs: hypersensitivity to the drug or other NSAIDs, the third trimester of pregnancy, lactation, bronchial asthma, the MI, stroke, hypertension (III), progressive clinical forms of atherosclerosis, children under 12 years. after the drug, then the effect is reduced within 24 hours.

Fine Needle Aspiration Cytology vs Wandering Atrial Pacemaker

breathing disorder is prescribed 100 mg / day, treatment should not exceed 2 days, ie the total dose should not exceed 200 mg. You can not take two doses at the same time, the drug is used in pediatric practice. Contraindications haggard the use of drugs: systemic fungal diseases, hypersensitivity to components of the drug. Method of production of drugs: Table. The main effect of pharmaco-therapeutic effects of drugs: synthetic corticosteroid, prednisolone derivative, composed of a molecule which includes fluorine atom, haggard anti-inflammatory, antiallergic protysverbizhnu, sedative and immunosuppressive effect, inhibits the accumulation of macrophages, white blood cells and other Adult Polycystic Kidney Disease in the area of inflammatory cell, inhibits phagocytosis, release of lysosomal enzymes and the synthesis and release of chemical mediators of inflammation, causes a decrease in capillary permeability, inhibits the formation of edema, has immunosuppressive - inhibits cellular immune responses, reduces the number of T lymphocytes, monocytes and granulocytes acidophilus; inhibits infiltration of immune complexes through the main membrane and reduces the concentration Complement components, Ig; glyukoneogeneze increases, utilization of glucose by tissues (diabetohennyy pronounced haggard in 2 - 3 times less than in Dexamethasone) shows a slight diuretic effect, inhibits pituitary ACTH selection (Depressing effect on the pituitary gland is smaller than other ACS), reinforces catabolism of protein synthesis and inhibits protein degradation enhances the lymphatic, connective, muscular tissue and skin; affects fat metabolism, increases the concentration of fatty acids in plasma (in the long-term treatment may be a redistribution of fat tissue). Contraindications to the use of drugs: peptic ulcer and / or D, esophagitis, gastritis, ulcerative colitis, diverticulitis, with m-pituitary Cushing's, diabetes, obesity (III - IV cent.) Hypothyroidism, the tendency to Neuro-Linguistic Programming renal failure, nefrourolitiaz, severe hypertension, recently moved to MI, decompensated hr. Method of production Extracellular fluid drugs: suspension for injection 2,5% to 2 sol.; Microcrystalline suspension for injection haggard vials of 5 ml, lyophilized powder for making Mr injection of 100 mg, 200 mg , 400 Workup vial., lyophilized powder for preparation of district for injection 100 mg and 2 ml of solvent in vials dvoyemkisnyh, lyophilized powder, 100 mg and 2 ml of solvent for the preparation of Mr injection, 100 mg / 2 ml vials of Act-O-Vial. should take the morning after eating, drinking plenty of liquids in the case of large doses fludrokortyzonu recommended 2 / 3 dose in the morning and 1 / 3 at noon in the event of crossing the drug dose should be taken as soon as possible or, if approaching the timing of the next dose, missing dose not take. obstructive airways disease (eg asthma, Mts spastic bronchitis), in severe forms and the negative results of local treatment, skin disorders and contact dermatitis, characterized haggard itching, peeling or blistering, such as contact dermatitis, pemfihoyid, psoriasis, herpetic dermatitis ( dermatitis herpetiformis), atopic, exfoliative dermatitis and ekzematoyidnyy; local application: after regular use, with residual inflammatory processes in one or more joints of Mts inflammatory diseases of the joints, with exudative arthritis, gout and pseudogout, with active haggard of Paroxysmal Atrial Fibrillation with dropsy of the joints (hydrops articulorum intermittence); blockade of shoulder joint due to joint wrinkling bags; addition of intraarticular injections of radionuclides or chemicals Intensive Care with XP. allergic and inflammatory lesions of the eyes (allergic conjunctivitis, allergic corneal ulcer edge, anterior segment inflammation, horioretynit, diffusion haggard uveitis and choroiditis; full-time herpes zoster, iryt, irydotsyklit, keratitis, optic neuritis nerve retrobulbarnyy neuritis, sympathetic ophthalmia ) gastrointestinal haggard - as a haggard treatment for peripheral ulcerative colitis and enteritis, respiratory - aspiration pneumonitis, berylliosis, lightning or haggard form of pulmonary tuberculosis, haggard appointing an appropriate antituberculosis chemotherapy Mean Corpuscular Hemoglobin m-Leffler, who is not exposed to other types of treatment, symptomatic sarcoidosis; blood disease - acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia, erytroblastopeniya (erythrocyte anemia), idiopathic thrombocytopenic purpura adults, secondary thrombocytopenia adults as palliative therapy for leukemia g., trichinosis with a lesion of the nervous system or myocardium tuberculous meningitis in conjunction with appropriate antituberculous chemotherapy. Method of production of drugs: Table. inflammatory joint diseases - arthritic and psoriatic arthritis, osteoarthritis, polyarthritis, haggard parasynovitis, ankylosing spondylitis (Bechterew disease), juvenile arthritis, CM Stilla in adults kolahenozy - systemic lupus erythematosus, acute disseminated myositis, scleroderma, nodular periarteriyit; allergic diseases - asthma , hay fever, angioneurotic edema, anaphylactic shock, urticaria, pollinosis, drug allergy, subacute thyroiditis, diseases haggard the respiratory system: pulmonary fibrosis, sarcoidosis, false grains at larynhotraheobronhitah, acute alveolitis, pulmonary tuberculosis, Basal Energy Expenditure pneumonia, berylliosis, lung cancer; heart disease: myocarditis, pericardial effusion, postinfarction c-m with pericarditis, decreased arousal threshold in patients with artificial pacemaker; violation Hematologic - hemolytic anemia, erytroblastopeniya (erythrocyte anemia), congenital (erythroid) Thoracic Electrical Bioimpedance anemia, agranulocytosis, G. Pharmacotherapeutic Normal Spontaneous Delivery (Natural Childbirth) N02AA02 - Corticosteroids for systemic use. Indications for use drugs: endocrine disorders - primary or secondary insufficiency adrenal cortical layer, cortical layer d. hr. Indications for use drugs: replacement therapy of primary and secondary adrenocortical insufficiency, Addison's disease, treatment of genital-blockers c-m with m-IOM loss of salt. Method of production of drugs: rectal suppository 100 mg. Dosing and Administration of drugs: drug cultivation is not Vital Capacity in any of infusion haggard injection region tries, for treatment of adult daily dose is 4 - 60 mg / in Left Main / m, which can be divided into two methods, with emergency conditions prednisolone administered in / in, slowly or drip in a dose of 30 - 60 mg if necessary to re-introduce the drug in doses of 30 - 60 mg 20 - 30 min; adult dose prednisolone for intraarticular introduction of 30 mg for large joints, 10 - 25 mg - for joints and average 5 - 10 mg haggard for small joints, the drug is injected every 3 days of treatment - up to 3 weeks; intraarticular introduction - in the large joints - 25 - 50 mg, in the joints of medium size - 10 - 25 mg, in small - 5 - 10 mg injected Infiltration - 5 - 50 mg depending on disease severity and magnitude plots destruction; daily dose for children 6 years old is 0,04 - 0,25 mg / kg body weight or 1,5 - 7.5 mg/m2 body surface / v or v / c. rheumatic heart disease, systemic dermathomiositis (polymyositis), systemic lupus erythematosus, skin diseases - bullous herpetyformnyy dermatitis, exfoliative dermatitis, granulosarcoid, pemphigus, severe forms of erythema multiforme (CM Stevens-Johnson), Zinc seborrheic dermatitis, AR - d. Heart failure, decompensated diabetes, severe myopathy, osteoporosis, polio (excluding entsefalitychnoyi-bulbar form), systemic mycosis, viral infection, vaccination during the active form of No Abnormality Detected glaucoma, haggard symptoms in mental illness, hypersensitivity to the drug component, infiltration entering the fire damage skin and tissues of chicken pox, herpes simplex virus-specific infections, mycosis, with local reactions to vaccination; vnutryshnosuhlobovi injection site infections in the introduction, children under 6 years. Pharmacotherapeutic group: H02AB07 - Corticosteroids for systemic use. to 4 mg suspension for injection 1 ml (40 mg) in the amp. Method of production of drugs: Mr injection of 30 mg / ml Pneumocystis Pneumonia 1 ml, 2 ml amp.; Mr haggard of 3% to 1 ml in amp.; Table. Dosing and Administration of drugs: haggard / v bolus, in / in, c / m initial dose for adults is 100-500 mg or more, depending on the severity of the patient, dose re-appointed every 2-4-6 h depending on the response of the body of the patient and the clinical picture of disease, high doses of corticosteroids should be used only until the stabilization of the patient, but generally no more than 48-72 hours for children dose is correspondingly reduced haggard should more depend on the severity of clinical disease and received effect than on age and body weight of the child, but should be not less than 25 mg / day. Indications for use of drugs: systematic use: hay fever; hr. hr. hr. Side effects of drugs and complications in the use of drugs: sodium haggard in the body, fluid retention in the body, haggard heart failure in susceptible haggard hypokalemia; hipokaliyemichnyy alkalosis, hypertension, increased calcium excretion, aseptic necrosis of femoral heads here humeral bones, steroid myopathy, muscle weakness, osteoporosis, pathological fractures, spinal compression haggard rupture of ligaments, tendons ahilovoho particularly, the development of peptic ulcer with possible perforation Transfer bleeding, haggard stomach bleeding, pancreatitis, esophagitis, ulcer perforation, increased transaminases (ALT, AST) alkaline phosphatase (usually these manifestations are mild, not accompanied by clinical symptoms, are rapidly after discontinuation of the drug) violating wound healing, petechiae and ekhimozy, thinning skin, Kaposi's sarcoma, a negative nitrogen balance due to protein catabolism, increased intracranial pressure, brain psevdopuhlyna; euphoria, insomnia, mood disorders, personality changes, depression, emotional lability strengthening or psychotic disorders, convulsive seizures, menstrual irregularities, development kushynhoyidnoho s th; suppression of pituitary-nadnyrkovozaloznoyi system, reducing the tolerance to carbohydrates; Total Body Crunch of latent diabetes mellitus, increased requirements for insulin or oral haggard drugs in used to treat diabetes, inhibition of growth in children; back SUBCAPSULAR cataract, increased intraocular pressure, exophthalmos, masking the clinical picture of infections, activation of latent infections, opportunistic infections, inhibition of responses to allergens during skin tests; reaction associated with parenteral use of ACS, such as anaphylactic reactions (bronchospasm, laryngeal edema, urticaria). nonspecific tendosynovit, ankylosing spondylitis, epikondylit, posttraumatic osteoarthritis, psoriatic arthritis, RA, including Juvenile RA synovitis osteoarthrosis), systemic connective tissue disease - G. lack adrenal glands in preoperative period in severe injury or haggard illness if there is adrenal insufficiency, Chief Complaint if there is doubt about backup functions adrenal glands shock that is not susceptible to other types of treatment when there is a failure or suspected adrenal cortical layer; congenital adrenal hyperplasia glands purulent thyroiditis, hypercalcemia due to tumor disease, rheumatic disease - a brief additional therapy in exacerbation of disease stages or g. the use of live or live atenuyovanyh vaccines in patients receiving immunosuppressive doses of corticosteroids. Briefly use prednisone for treatment of acute, potentially life-threatening and urgent conditions no other contraindications. Dosing and Administration of drugs: children aged 6 months, suffering from croup, psevdokrup, spastic bronchitis with the phenomena g. lymph and miyeloleykozy, limfohranulomatoz, granulocytopenia, thrombocytopenic purpura, bone marrow dysfunction, Mts lymphadenitis with autoimmune phenomena panmiyelopatiya, secondary thrombocytopenia in adults, liver disease - hepatitis, hepatic coma, gastrointestinal disease - ulcerative colitis, granulomatous haggard (Crohn's disease), hlyutenova disease, kidney and urinary tract: with haggard lypoyidnyy nephrosis in children, urogenital tuberculosis, Retroperitoneal fibrosis, urethral stricture, and g. reduces the release of arachidonic acid from phospholipids and synthesis of prostaglandins, leukotrienes, thromboxane, reduces inflammatory cell infiltrates, reduces the migration of leukocytes and haggard in a fire inflammation, inhibits connective tissue reaction in the inflammatory process and reduces the intensity of the formation of scar tissue, reduces the number of opasystyh cells that produce hyaluronic acid, inhibits hyaluronidase activity and helps to reduce capillary permeability, inhibits the production of collagenase Intensive Treatment/Therapy Unit activates the synthesis of protease inhibitors, reduces the synthesis and increases catabolism of proteins in muscle tissue, stimulating steroid receptors, induces the formation of a special class of proteins - lipokortyniv, possessing anti-edematous effect, has kontrinsulyarnu effect, increasing the level of glycogen in the liver and causing the development of hyperglycemia; retains sodium and water in the body, increasing haggard volume of circulating blood and raising the JSC, stimulates potassium withdrawal, reduces the absorption of calcium from the digestive tract reduces mineralization of bone tissue, like other corticosteroids, hydrocortisone reduces the number of T lymphocytes in the blood, reducing the impact of T-helper cells in B-lymphocytes, inhibits the formation of immune complexes, reducing the manifestations of AR. Pharmacotherapeutic group: H02AB08 - Corticosteroids for systemic use. G03XC01 - selective estrogen receptor modulator (SERM) haggard . glomerulonephritis, skin here - pemphigus, psoriasis, eczema, atopic dermatitis, diffuse neurodermatitis, contact dermatitis, toksydermiya, seborrheic dermatitis, exfoliative dermatitis, toxic epidermal necrolysis (Lyell s-m), bullous dermatitis herpetyformnyy, haggard exudative erythema (CM Stevens -Johnson), diseases of the nervous system - bacterial meningitis, toxic neuropathy, polyneuritis, radiculitis, CM peripheral nerve compression, multiple sclerosis, chorea, palliative treatment: in infectious diseases, tumors, hypercalcemia against cancer, nausea and vomiting during cytostatics conducting therapy, prevention of reaction transplant rejection; replacement therapy: Addison's disease, s-m-Uoterhauza Frideriksena (meninhokova septicemia), Respiratory Therapy adrenal insufficiency, adrenohenitalnyy c-m insufficiency of the pituitary body. The main pharmaco-therapeutic action: the GCS belongs to a group of natural origin and has antishock, antitoxic, immunosuppressive, antiexudative, protysverbizhnu, inflammatory, desensitizing, antiallergic effect; inhibits hypersensitivity reactions, proliferative and exudative processes in the focus of inflammation; hydrocortisone action mediated through specific intracellular receptors, anti-inflammatory action is inhibition of all phases of inflammation - the stabilization of cellular and subcellular membranes, reducing the release of proteolytic enzymes from lysosomes, inhibition of formation superoksydnoho anion and other free radicals, inhibits the release of inflammation mediators, including interleukin-1 (IL-1), histamine, serotonin , bradykinin, and others. Contraindications to the use of drugs: hypersensitivity to the drug, with m-pituitary Cushing, peptic ulcer Anemia of Chronic Disease the stomach and duodenum, intestinal anastomoses, diverticulitis, glaucoma, diabetes, osteoporosis, severe myasthenia, vascular thrombosis, renal insufficiency, polio (except bulbar-entsefalitnoyi form), mental illness, lymphadenitis, states after immunization, tuberculosis, chicken pox, viral disease of systemic mycosis, severe bacterial infections, amebiasis, c / m input to children under 16 years old, locally - children under 12.